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Larry PalmerLarry Palmer
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University of Pennsylvania
School of Dental Medicine
121 Johnson Pavilion
Philadelphia, PA 19104

Office: 121 Johnson Pavilion
Office phone: 215.898.0992
Fax: 215.573.9050
E-mail: palmerl@mail.med.upenn.edu


Research Interests
Studies are on-going in two, related major areas: extracellular studies of the context dependency of responses elicited from the classical receptive fields (CRF) of neurons in cat primary visual cortex and intracellular studies of lateral, horizontal inputs to these same cells.

We have found that the responses of about half of the direction selective cells in primary visual cortex can be strongly influenced, sometimes even overwhelmed, by moving stimuli situated entirely outside the CRF. The centers and surrounds have an opponent organization--surround motion in the null direction facilitates the center response and surround motion in the preferred direction inhibits the center response. By estimating spatiotemporal receptive field structure both with and without effective surround stimuli, we have determined that the surround effects are effected by changes in gain of the CRF mechanism rather than changes in RF structure. Thus the filters are scalable but not tunable.

In the intracellular studies, we are using spike-triggered averaging of membrane potential locked to extracellular activity of groups of neurons recorded extracellularly at various distances in visual space and as a function of orientation difference. With this approach, we hope to establish patterns of connectivity and to explore the synaptic mechanisms underlying context dependency in visual cortex.

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Last modified: 5 June, 2006